When someone is diagnosed with T1D, there is significant beta cell loss, blood sugars are dangerously high and symptoms are present
Flow changes: Are you noticing lighter or heavier bleeding, clots, or spotting between periods
However, if the redness spreads rapidly, becomes very painful, or is accompanied by hives and trouble breathing, seek emergency medical care as these could be signs of a serious allergic reaction
Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice